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CORO1C, a novel PAK4 binding protein, recruits phospho-PAK4 at serine 99 to the leading edge and promotes the migration of gastric cancer cells.
Li X, Chen M, Yuan Y, Li J, Li F. Li X, et al. Acta Biochim Biophys Sin (Shanghai). 2022 May 25;54(5):673-685. doi: 10.3724/abbs.2022044. Acta Biochim Biophys Sin (Shanghai). 2022. PMID: 35593474 Free PMC article.
The localization of PAK4 on the leading edge of the cell depends on two necessary conditions: the phosphorylation of PAK4 on serine 99 and the binding to the CE domain of CORO1C. Unphosphorylated PAK4 on serine 99 is closely associated with microtubules by …
The localization of PAK4 on the leading edge of the cell depends on two necessary conditions: the phosphorylation of PAK4 on s …
Activated Pak4 expression correlates with poor prognosis in human gastric cancer patients.
Li D, Zhang Y, Li Z, Wang X, Qu X, Liu Y. Li D, et al. Tumour Biol. 2015 Dec;36(12):9431-6. doi: 10.1007/s13277-015-3368-4. Epub 2015 Jun 30. Tumour Biol. 2015. PMID: 26124003
However, it is still unclear if activated Pak4 (p-Pak4) is related to prognosis in GC patients. In our study, the level of p-Pak4 in 95 GC tissue specimens was examined by immunohistochemistry (IHC). ...Moreover, GC patients with higher p-Pak4 levels h …
However, it is still unclear if activated Pak4 (p-Pak4) is related to prognosis in GC patients. In our study, the level of p- …
Oncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesis.
Wang C, Li Y, Zhang H, Liu F, Cheng Z, Wang D, Wang G, Xu H, Zhao Y, Cao L, Li F. Wang C, et al. Oncogene. 2014 Jun 26;33(26):3473-84. doi: 10.1038/onc.2013.300. Epub 2013 Aug 12. Oncogene. 2014. PMID: 23934187
First, PAK4 interaction with Smad2/3, which is independent of PAK4 kinase activity, blocks TGF-beta1-induced phosphorylation of Smad2 Ser465/467 or Smad3 Ser423/425 and the consequent activation. ...Our results document an oncogenic role of PAK4 in repression …
First, PAK4 interaction with Smad2/3, which is independent of PAK4 kinase activity, blocks TGF-beta1-induced phosphorylation o …
Prognostic significance of PAK4 expression in gastric cancer.
Kobayashi K, Inokuchi M, Takagi Y, Otsuki S, Fujimori Y, Sato Y, Yanaka Y, Higuchi K, Aburatani T, Tomii C, Uetake H, Kojima K, Kawano T. Kobayashi K, et al. J Clin Pathol. 2016 Jul;69(7):580-5. doi: 10.1136/jclinpath-2015-203330. Epub 2015 Nov 27. J Clin Pathol. 2016. PMID: 26614788
AIMS: p-21 activated kinase (PAK) 4, part of the six PAK families, plays an important role in growth factor signalling, cytoskeletal remodelling, gene transcription, cell proliferation and oncogenic transformation. However, the clinical significance of PAK4 in gastric canc …
AIMS: p-21 activated kinase (PAK) 4, part of the six PAK families, plays an important role in growth factor signalling, cytoskeletal remodel …
MiR-199a/b-3p inhibits gastric cancer cell proliferation via down-regulating PAK4/MEK/ERK signaling pathway.
Zeng B, Shi W, Tan G. Zeng B, et al. BMC Cancer. 2018 Jan 5;18(1):34. doi: 10.1186/s12885-017-3949-2. BMC Cancer. 2018. PMID: 29304764 Free PMC article.
RESULTS: MiR-199a/b-3p expression was significantly decreased in GC tissues and GC cell lines MGC-803 and SGC-7901. MiR-199a/b-3p over-expression and PAK4 silencing inhibited cell proliferation and diminished the activation of p-MEK and p-ERK in MGC-803 and SGC-7901 cells, …
RESULTS: MiR-199a/b-3p expression was significantly decreased in GC tissues and GC cell lines MGC-803 and SGC-7901. MiR-199a/b-3p over-expre …
PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways.
Fu X, Feng J, Zeng D, Ding Y, Yu C, Yang B. Fu X, et al. Biosci Rep. 2014 Apr 1;34(2):e00094. doi: 10.1042/BSR20130102. Print 2014 Apr 1. Biosci Rep. 2014. PMID: 27919028 Free PMC article.
Inhibition of PAK4 or knockdown of PAK4 expression by specific siRNA (small interfering RNA)-sensitized CDDP-resistant cells to CDDP and overcome CDDP resistance. ...PAK4 and PI3K/Akt pathways can reciprocally activate each other. ...
Inhibition of PAK4 or knockdown of PAK4 expression by specific siRNA (small interfering RNA)-sensitized CDDP-resistant cells t …
LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells.
Zhang J, Wang J, Guo Q, Wang Y, Zhou Y, Peng H, Cheng M, Zhao D, Li F. Zhang J, et al. Cancer Lett. 2012 Apr 1;317(1):24-32. doi: 10.1016/j.canlet.2011.11.007. Epub 2011 Nov 13. Cancer Lett. 2012. PMID: 22085492
In this paper we found that LCH-7749944, a novel and potent PAK4 inhibitor, effectively suppressed the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway. ...Importantly, LCH-7749944 caused successful inhibition o …
In this paper we found that LCH-7749944, a novel and potent PAK4 inhibitor, effectively suppressed the proliferation of human gastric …
Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population.
Li WQ, Hu N, Wang Z, Yu K, Su H, Wang L, Wang C, Chanock SJ, Burdett L, Ding T, Qiao YL, Fan JH, Wang Y, Xu Y, Giffen C, Xiong X, Murphy G, Tucker MA, Dawsey SM, Freedman ND, Abnet CC, Goldstein AM, Taylor PR. Li WQ, et al. PLoS One. 2013 Jul 18;8(7):e68999. doi: 10.1371/journal.pone.0068999. Print 2013. PLoS One. 2013. PMID: 23874846 Free PMC article.
For ESCC, we did not observe a significant pathway-level association (P = 0.72), but gene-level analyses suggested associations between GNAI3, CHRNE, PAK4, WASL, and ITCH, and ESCC (P<0.05). Our data suggest an association between specific genes in the EGFR signaling pa …
For ESCC, we did not observe a significant pathway-level association (P = 0.72), but gene-level analyses suggested associations between GNAI …